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Long term cure rates after permanent radio-isotope brachytherapy for early prostate cancer

Investigators led by Dr. Louis Potters (New York Prostate Institute) enrolled 1449 men with T1b-T2c prostate cancer between 1991 and 2000 and treated with permanent brachytherapy. In actuarial analysis, the 12 year disease specific survival was 95%. The 12 year rate of biochemical 'failure-free survival' was 78% for the entire cohort, varying from 89% for the lowest risk group (low Glesason score, low PSA and low number of biopsies positive) to 78% for the intermediate group and 63% for the higher risk group. These data, presented at the American Society for Therapeutic radiology meeting, provide another long term follow up study validating prostate brachytherapy as a low toxicity and highly effectiv and durable radical treatment for this disease.