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Targeted therapy delivers toxin to glioblastoma cells

Interleukin 13 receptor is overexpressed by glioblastoma cells but minimally by normal brain cells. Aiming to exploit this difference, workers from UCSF have coupled cintredekin besudotox to IL13 and infused this, via catheters positioned at surgery, into the tumour - hoping that the toxin will be selectively conveyed to the tumour. Early reports suggest limited success and the trials continue.