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The delivery of drugs that kill cells either by interrupting DNA viability or its ability to replicate in cell division, or by poisoning vital metabolic pathways. It should be noted that there is often nothing tumour selective about chemotherapy and other strategies may have to be used to improve the therapeutic ratio on the tumour (i.e. killing more cancer cells than normal ones). One common strategy capitalises on the fact that normal cells sense (chemotherapeutic) damage, and recruit repair mechanisms more rapidly than tumour cells; therefore, the repetitive administration of chemotherapy every few weeks can lead to a preferentially toxic effect on cancer cells.

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